In the city where Shiki lives, something triggers a spate of mysterious schoolgirl suicides. The connection between the girls who leapt to their deaths is unclear, although all of them have jumped from the Fujou Building, a skyscraper scheduled to be demolished. Meanwhile, Mikiya, after having gone near the Fujou Building, has fallen into a coma. Shiki heads to the Fujou Building herself to save Mikiya. And waiting for her there…is Kirie Fujou. The girls' suicides and Mikiya's coma were all caused by Kirie. Terminal illness had left her bedridden and immobile in a hospital, but one day, she acquires a spiritual body, a separate entity from herself.

(Source: Aniplex USA)